Nutricia Allergy HCP

Topic

Revolutionizing nutritional strategies in early life allergy prevention and management

Chairmen

Dr. Marco Ho
President, Hong Kong Institute of Allergy
Specialist in Paediatric Immunology & Infectious Diseases

Prof. Udo Herz
Professor for Immunology and Laboratory Medicine, University Hospital Marburg, Germany
Global Science Director, Danone Nutricia

Speakers

Prof. Nikos Papadopoulos
Professor of Allergy and Paediatric Allergy, University of Manchester, UK
Chair of Allergy and Pediatric Allergy, University of Athens, Greece

Prof. Ting-Fan Leung
Chairman and Professor, Department of Paediatrics, The Chinese University of Hong Kong

Prof. Jan Knol
Professor, Intestinal Microbiology of Early Life, Wageningen University, the Netherlands
Director, Gut Biology & Microbiology, Danone Nutricia Research, the Netherlands

Dr. Elena Sandalova
Senior Scientist in Immunology, Danone Nutricia Research, Singapore

Ms. June Chan
Senior Dietitian, Allergy Centre, Hong Kong Sanatorium & Hospital, Hong Kong

Dr. Rosan Meyer
Paediatric Allergy Research Dietitian, Kings College, London
Honorary Senior Lecturer, Imperial College, London UK
Visiting Professor, KU Leuven, Belgium

23 JUN 2019 (SUN)

11:30 - 12:15
Registration and lunch buffet

12:15 - 13:35
Lectures
Q&A

13:35 - 13:45
Tea Break

13:45 - 15:15
Lectures
Q&A

15:15 - 15:30
Tea Break

15:30 - 16:15
Lectures
Q&A

16:15 - 16:25
Closing Remarks

Grand Ballroom, Grand Hyatt Hong Kong, 1 Harbour Road, Wan Chai, Hong Kong

About the Chairman - Dr. Marco Ho

Dr. HO, Hok-kung Marco 何學⼯醫⽣
Specialist in Paediatric Immunology & Infectious Diseases
M.B.B.S. (H.K.) 1994 M.D. (H.K.) 2016, M.R.C.P. (U.K.) 1998
F.H.K.C. Paed 2002, F.H.K.A.M. 2002
F.R.C.P.C.H. 2016, F.R.C.P. (Edinburgh) 2017, F.R.C.P. (London) 2018.

Dr Ho graduated at HKU in 1994 and completed training in Paediatrics 1995-2001 and in Allergy & Clinical Immunology 2001-03. He was a Research Fellow at Royal Children Hospital, Melbourne 2005-06. He completed his MD thesis entitled Clinical Care of Food Allergy/Anaphylaxis in Children and was awarded Sir Patrick Manson Gold Medal. He inaugurated a new Allergy Immunotherapy Clinic at QMH in 2003. Dr Ho is one of the first few registered Specialist in Paediatrics Immunology & Infectious Diseases at Medical Council since 2012. He was a former Consultant Paediatrician of Queen Mary Hospital where he served for over 24 years. He was the lead clinician of Allergy & Immunology for 12 years and awarded QMH’s Outstanding Staff for his clinical excellence in diagnosing and treating various rare and complex immunological disorders.

He was appointed Service Director of Quality & Safety (2015-18) and Deputy Hospital Chief Executive before he moved to private practice. He is an Honorary Clinical Associate Professor of HKU. Dr Ho was admitted Fellows to many learned institutes including Royal Colleges, American College of Allergy, Asthma and Immunology and Australasian Society of Clinical Immunology and Allergy. Dr Ho was the Founding Council of HK Paediatric Society for Immunology, Allergy and
Infectious Disease where he served as Hon. Secretary 2010-14 and Vice President 2014-18. He is the elected President 2017-19 of HK Institute of Allergy.

Dr Ho is one of the Founders, past-Chairman and Advisor of HK Allergy Association, a charitable patient support organization founded since 2008. He is an Advisor to HK Asthma Society. Dr Ho has authored and co-authored over 90 peer reviewed journal articles on topics covering general paediatrics, vaccines, infectious diseases, immunology, allergy and rheumatology. Dr Ho has published a series of books written in Chinese for educating public on proper community allergy care which was bestowed the prestigious HKU Knowledge Exchange Award 2011. Dr Ho is currently doing private practice and he is the Director of Paediatric Allergy Immunology & Rheumatology at Virtus Medical Group, Hong Kong.

About the Chairman - Prof. Udo Herz

Prof. Dr. Udo Herz:

Danone Nutricia, Health Care Nutrition, Global Science Director
Associate Professor for Immunology and Laboratory Medicine at the Philipp’s University of Marburg & Giessen, Germany
President of Specialized Nutrition (SNE), Brussels, Belgium.

Education:
Master of Science degree in Biology, Robert Koch-Institute, Berlin
1994, PhD in Molecular Biology & Immunology, Eberhard-Karls-University, Tübingen.
1994 to 1999, Senior Research Scientist, Virchow Clinic of the Free University of Berlin, Institute for Clinical
Chemistry, Germany. Work on impact of environmental factors impacting the development of allergies and asthma, with special focus on the impact of early exposure to microbes.
2000 to 2003, University Hospital of the Philipp’s-University Marburg, Department of Clinical Chemistry and Molecular Diagnostics, Head of Research and Development. Continued research on factors which could prevent the onset of allergies especially on bacterial components and their capacity to modulate the immune response.
2001, Associate Professor for Immunology and Laboratory Medicine at the Philipp’s University of Marburg & Giessen, in Germany, working on infections in the immune - pathogenesis of allergy and asthma but also the role of probiotics for allergy prevention.
2002, guest Professor at the University of Salzburg, Institute for Chemistry and Biochemistry.

Professional Assignments:
2003, Mead Johnson Nutrition as Senior Principal Research Scientist, responsible for the company’s Global Allergy & Tolerance Technology Platform and external R&D program.
2005, Mead Johnson Nutrition, Director Research & Development Europe, heading the departments of Regulatory and Scientific Affairs, Nutrition Science, Product Development & Engineering and Process Management.
2014, Danone/Nutricia Early Life Nutrition, Director for Global Program Infant Formula, Utrecht, Netherlands.
Since 2015, , Danone/Nutricia Early Life Nutrition, Global Science Director, HealthCare Nutrition, Amsterdam, the Netherlands.
Author of > 100 publications in pre-reviewed journals and book chapters

Industry Association:
2013, Board Member of the European Industry Association of Specialized Nutrition (SNE), Brussels, Belgium.
Since 2017, President of Specialized Nutrition (SNE), Brussels, Belgium.

About the Speaker - Prof. Nikos Papadopoulos

Nikolaos (Nikos) Papadopoulos is Professor of Allergy and Paediatric Allergy at the University of Manchester, UK. He has also the Chair of Allergy and Pediatric Allergy at the University of Athens (NKUA), Greece. He has extensive clinical and educational experience in Paediatric Allergy, having headed for many years a unit caring for more than 7000 children with allergic diseases yearly, implementing state-of-the-art interventions and training medical students, resident pediatricians and allergists. His research focus is the interphase between infection andallergic disease, with emphasis in asthma exacerbations and food allergy. He is the Co-ordinator of the EU- funded project CURE. He has extensive collaborations in the context of EU Projects, such as PreDicta, GA2LEN, EUROPREVALL, iFAAM and FAST. Prof Papadopoulos has published over 300 papers (h-index: 69), has received several international awards and is invited to speak at international scientific meetings some 30 times a year. Moreover, he has/is serving in Boards of EAACI, GA2LEN, WAO, EFA and ARIA. He was the 2013-2015 President of EAACI and is currently the President of the Respiratory Effectiveness Group (REG).

About the Speaker - Prof. Ting-Fan Leung

Professor Leung graduated from the Chinese University of Hong Kong in 1992, and he received subspecialty training on Immunology and Allergy in the Hospital for Sick Children in Toronto, Canada in 1997-1998. He was awarded Doctor of Medicine degree by The Chinese University of Hong Kong in 2004 for his research works on immunogenetics of childhood asthma. In addition to being a Fellow of Royal College of Paediatrics and Child Health, Professor Leung was elected as an International Fellow of the American Academy of Allergy, Asthma and Immunology in 2011. He was conferred as a First Fellow in Paediatric Immunology and Infectious Diseases subspecialty by the Hong Kong College of Paediatricians in 2012. Professor Leung is a professor in Department of Paediatrics of the Chinese University of Hong Kong since 2009,and he resumed Chairmanship in the Department since 2014. He is also honorary consultant paediatrician in both the New Territories East Cluster Hospitals and Kwong Wah Hospital of the Hospital Authority. Professor Leung is a member of the Grant Review Board of Health and Medical Research Fund in Hong Kong. He is also an overseas member of the review board for nationwide research grants in the Ministry of Education of the People's Republic of China. Professor Leung is Secretary-General of the Asia Pacific Association of Paediatric Allergy, Respirology and Immunology, Vice President of the Hong Kong Society for Paediatric Immunology and Infectious Diseases and a fellow or member of over 10 other international and regional subspecialty organizations. Professor Leung published more than 280 refereed journal articles and supervised one post-doctoral fellow and 22 master and doctoral students. Professor Leung serves as editor, editorial board member or reviewer for over 60 international journals in the fields of allergy, immunology, infectious diseases, pulmonology, dermatology and genetics.

About the Speaker - Prof. Jan Knol

Title and Position	Professor Intestinal Microbiology of Early Life Wageningen University Director Gut Biology & Microbiology Danone Nutricia Research Utrecht/Singapore
Education	University of Groningen Biochemistry and Microbiology
Description	Prof. dr. Jan Knol is Director of the Gut Biology & Microbiology Platform at Danone Nutricia Research, Utrecht (The Netherlands) and Singapore since 2010. He is responsible for the gut and microbiology related research programs focussing on nutrition and health. The platform brings together unique expertises in the area of microbiology and human (gut) physiology to substantiate nutritional concepts and to develop innovative products for both the Baby Nutrition and Medical Nutrition Divisions of Danone. In addition, since April 2012, Jan is Special Professor of Intestinal Microbiology of Early Life at the Laboratory of Microbiology at the Wageningen University. The chair focusses on the early colonisation of the intestinal tract of newborn infants linked also to potential health outcomes. Jan studied biology / biochemistry with specialisations in molecular biology and microbiology at the University of Groningen, The Netherlands. He completed his PhD thesis in 1999 at the University of Groningen on sugar transport mechanisms in lactic acid bacteria. Part of this work was performed at the University of Leeds (United Kingdom) and the “Laboratoire J. Maetz” in Villefranche sur mer (France). After his PhD he started as a scientist at Nutricia Research in Wageningen. After several years as research manager Microbiology he is now leading an expertise group on Gut Biology and Microbiology, with projects focussing on pre- and probiotics, intestinal microbiota, digestion and gut health. Jan Knol published more than 125 peer reviewed papers in the field of microbiology and gut biology (h-index 44), and is inventor of more than 25 patent applications.

About the Speaker - Dr. Elena Sandalova

Contact	Email: elenasandalova@gmail.com mobile: 65-96646302
Professional Links	Publications: https://scholar.google.com.sg/citations?user=PNVfMvAAAAAJ&hl=en Linkedin profile: https://www.linkedin.com/in/elena-sandalova-51a5b21/?ppe=1
Education	MSc in Biology, Siberian State University, Krasnoyarsk, Russia, 2001 PhD in Immunology, Karolinska Institute, Stockholm, Sweden, 2007 Collaborative Institutional Training Initiative (CITI) Good Clinical Practice Course, 2013 Responsible Care and Use of Laboratory Animals course, A Star, 2005
Working Experience	• Senior Scientist Immunology, Danone Nutricia Research, 2012-current • Project Lead Digital Allergy, Danone Nutricia Research, 2018-current • Principal Investigator, Danone Nutricia Research, Understanding innate and adaptive immunological response in stool and saliva samples in healthy donors, PIEC/2014/036, 2014-2017 • Principal Investigator, Danone Nutricia Research, Validation of Food Frequency Questionarie and inflammatory biomarkers in saliva in toddlers in Singapore, PIEC/ 2014/036, 2015-2017 • PhD company supervisor, PHD EDB IPP program, Biomarkers of atopic dermatitis in umbilical cord, 2013-2018 • Team Leader Immunology, Danone Nutricia Research, 2012-2017 • Senior Research Fellow, Singapore Institute for Clinical Sciences, A Star, 2010-2012 • Research Fellow, Singapore Institute for Clinical Sciences, A Star, 2007-2010 • Research Fellow, Division of John’s Hopkins Institute in Singapore, 2005-2007 • English Teacher, Primary Public School 41, Krasnoyarsk, Russia, 1993-1994
Research Interests and Teaching Experience	Danone Nutricia Research Early Life Nutrition: current employment. The research focus is on Early Life Nutritional Programming, the effect of nutrition on the development of the immune system. Particular interest in early nutrition’s potential to improve the balance of the immune system towards reduction of allergy while maintaining or improving responses against infections; the interaction of gut microbiota with the immune system as well as the direct effect of the nutrients on immune system. We are also developing the methodology to address these questions of interest, such as development and validation of non-invasive biomarkers of immune responses; the interactions in the gut and the research on risk factors of allergy; effect of nutrition on vaccination and infection responses. Recently, I have engaged in the development of digital tools for management, prevention of allergies. Singapore Institute for Clinical Sciences: The project is focused on characterizing cellular responses to Hepatitis B Virus in the blood and in the liver. The work is explaining the mechanisms of T cell responses that are functional during acute/chronic hepatitis B infection in humans. In parallel with the discoveries of new T cell epitopes, characterization of the functionality and cooperation of cellular responses during primarily hepatitis B infection was explored; In addition, responses to Influenza, dengue virus and several other human infections were assessed. The second major project is studying the immune responses and their functions in healthy human liver (obtained from perfusions of donor liver prior to transplant). Isolation of different cell population from healthy liver perfusions was performed in order to study their immune function in comparison with healthy peripheral blood. Division of Johns Hopkins in Singapore: November 2005 to January 2007. This work generated a deeper understanding of alternative mechanisms of Activation Induced cell death in T cells which undergo repetitive and strong activation. We have described these mechanisms in an in vitro model and have proven that the same events are taking place during acute infection with Epstein-Barr virus in humans in case of acute infectious mononucleosis. Analyzing the in vitro activation and ex vivo samples from the patients with primary EBV infection we were able to show which apoptotic molecules and mechanisms are responsible for driving T cells into apoptosis after strong activation stimuli. This project enabled me with extensive knowledge about EBV as well as other herpesviruses. Public School N41, Krasnoyarsk, Russia: During school year of 1993-1994 I took upon a challenge in the public school N41, which specialized in teaching spoken and written English. I taught Basic Beginner level English language to a group of students with behavioral difficulties. These children were far behind the learning schedule and my task was to get them back to the level required for primary year 2. After one year of additional classes they were able to join the normal group of students.

About the Speaker - Ms. June Chan

Education Background / Professional Certification	• March 2007 Master of Science in Exercise and Nutrition Science with Distinction University of Liverpool (U.K.) • April 2003 Accredited Dietitian Hong Kong Dietitians Association • August 1999 Dietitian Registration (U.S.A.) CDR 86084 Commission of Dietetic Registration, U.S.A • September 1998 Post-Baccalaureate Dietetic Internship (12-month Generalist Program in Dietetics) Yale-New Haven Hospital, New Haven, Connecticut, U.S.A. • June 1997 Bachelor of Science in Dietetics, High Honors University of California, Davis, California, Untied States www.ucdavis.edu
Professional Achievements	Past President (2003 – 2004; 2005-2006) Hong Kong Nutrition Association Ltd. www.hkna.org.hk Outstanding Contributions as an Allied Health Professional in Allergic Diseases Award (2016) Hong Kong Institute of Allergy
Professional Experience	• March 2012 to Date Senior Dietitian, Allergy Centre Hong Kong Sanatorium & Hospital www.hksh.com • March 2004 to August 2014 Senior Dietitian, Department of Health Assessment; Endocrine & Diabetes Centre Hong Kong Sanatorium & Hospital www.hksh.com • August 2003 to August 2004 Consulting Dietitian (Part-time) Mong Kok Kai Fong Association Ltd. Chan Hing Social Service Centre, Hong Kong • October 2002 to August 2004 Outpatient Dietitian (Part-time) Practicing Teacher Union Health Project Medical Center Hong Kong www.hkptu.org.hk • January 1999 to March 2004 Dietitian in-charge / Lifestyle Consultant Matilda International Hospital, Hong Kong www.matilda.org
Publications	• Ho, M.H., J. Chan, and T.H. Lee, (2014) Guideline for the diagnosis and management of cow’s milk protein allergy CMPA) in Hong Kong, Hong Kong Institute of Allergy Hong Kong • Lee, T.H., et al., Immunotherapy for peanut allergy. Hong Kong Med J, 2014. 20(4): p. 325-30. • Chan J., et al. (2015) HKIA Position Paper on Prevention of Peanut Allergy in High Risk Infants Hong Kong Institute of Allergy Hong Kong • Chan, A. W., et al. (2016). "Guidelines for allergy prevention in Hong Kong." Hong Kong Med J 22(3): 279-285. • Lee, T. H., et al. (2017). "Immunoglobulin G testing in the diagnosis of food allergy and intolerance." Hong Kong Med J 23(4): 419-420. • Ho, M.H., J. Chan, and T.H. Lee, Guideline for the diagnosis and management of cow’s milk protein allergy CMPA) in Hong Kong 2014, Hong Kong Institute of Allergy Hong Kong • Chan JKC et al. A Study on Maternal Diet and Prospective Allergenic Solid Food Introduction among Chinese Infants Surveyed in a Private Hospital in Hong Kong. DOI: 10.24966/PPN-5681/100008 READ LESS

About the Speaker - Dr. Rosan Meyer

Rosan completed her degree in Dietetics in South Africa and specialised in paediatric nutrition in the UK. In 2004, she finished her MSc in Paediatric Nutrition and in 2008 her PhD at Imperial College London. She was the principal research dietitian at Great Ormond Street Hospital for Children until December 2015, leading a project on the impact of gastrointestinal food allergies on children and their families and after this worked with the allergy team at St. Thomas Hospital as research dietitian until 2018. In addition, she has a busy paediatric dietetic practice specialising in food allergy, feeding difficulties and faltering growth in London. She has published numerous articles on paediatric nutrition, food allergy, feeding difficulties and is in particular interested in the association between growth and food allergy.
She is currently module leader for the Food Hypersensitivity Module that forms part of the MSc in Allergy at Imperial College London, and is honorary senior lecturer in paediatrics at the same university. She is also visiting Professor at KU Leuven, Belgium, on their MSc on Swallow Disorders. She is the chair of the European Section of the International Network for Diet and Allergy, secretary of the Allied Health and Primary Care Interest Group of EAACI and member of several EAACI task forces on food allergy.

About the Event

11:30 - 12:15	Registration and lunch buffet
12:15 - 12:20	Opening speech by the Chairmen Dr. Marco Ho President, Hong Kong Institute of Allergy Specialist in Paediatric Immunology & Infectious Diseases Prof. Udo Herz Professor for Immunology and Laboratory Medicine, University Hospital Marburg, Germany Global Science Director, Danone Nutricia
12:20 - 12:55	Food allergy prevention – where are we now? Prof. Nikos Papadopoulos Professor of Allergy and Paediatric Allergy, University of Manchester, UK Chair of Allergy and Pediatric Allergy, University of Athens, Greece
12:55 - 13:25	Is microbiota the solution for addressing allergies in Hong Kong? Prof. Ting-Fan Leung Chairman and Professor, Department of Paediatrics, The Chinese University of Hong Kong
13:25 – 13:35	Q&A
13:35 – 13:45	Tea break
13:45 - 14: 05	The role of nutrition in gut microbiota development and early life immunity Prof. Jan Knol Professor, Intestinal Microbiology of Early Life, Wageningen University, the Netherlands Director, Gut Biology & Microbiology, Danone Nutricia Research, the Netherlands
14:05- 14:25	The latest clinical evidence for the reduction of allergy development in at risk population and future prospect of a unique synbiotic combination Dr. Elena Sandalova Senior Scientist in Immunology, Danone Nutricia Research, Singapore
14:25 - 14:35	Q&A
14:35 - 15:05	Maternal dietary avoidance and solid food introduction planning among parents of Chinese infants Ms. June Chan Senior Dietitian, Allergy Centre, Hong Kong Sanatorium & Hospital, Hong Kong
15:05 - 15:15	Q&A
15:15 - 15:30	Tea break
15:30 – 16:05	Translating the latest scientific insights for the dietary management of allergy into clinical practice Dr. Rosan Meyer Paediatric Allergy Research Dietitian, Kings College, London Honorary Senior Lecturer, Imperial College, London UK Visiting Professor, KU Leuven, Belgium
16:05- 16:25	Q&A & Closing remarks by the Chairmen Dr. Marco Ho President, Hong Kong Institute of Allergy Specialist in Paediatric Immunology & Infectious Diseases Prof. Udo Herz Professor for Immunology and Laboratory Medicine, University Hospital Marburg, Germany Global Science Director, Danone Nutricia

23 JUN 2019 (SUN)

Grand Ballroom, Grand Hyatt Hong Kong, 1 Harbour Road, Wan Chai, Hong Kong